Published on 08 Sep 2025
A new study explains why Huntington’s disease (HD) symptoms appear in midlife despite the gene mutation being present from birth.
Genes are composed of sequences made from four nucleotide bases—adenine (A), cytosine (C), guanine (G), and thymine (T)—arranged in various combinations.
Huntington's disease is caused by an inherited mutation in the Huntington (HTT) gene in which a three-letter DNA sequence, C-A-G, is repeated at least 40 times.
HD damages the nerve cells (neurons) that help to control voluntary (intentional) movement, as well as other areas.
People living with HD develop uncontrollable dance-like movements (chorea) and abnormal body postures, as well as problems with behavior, emotion, thinking, and personality.
Huntington’s Disease
HD
Diseases
Health
Genetic disease
Mutation
Gene Therapy
Genetic engineering